Modification of C Terminus Provides New Insights into the Mechanism of α-Synuclein Aggregation
نویسندگان
چکیده
منابع مشابه
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.
Intracytoplasmic proteinaceous inclusions, primarily composed of tau or α-synuclein (α-syn), are predominant pathological features of Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. However, the coexistence of these pathological aggregates is identified in many neurodegenerative disorders, including spectrum disorders of AD and PD. Whereas α-syn can spontaneously polymerize...
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a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. b Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London WC1N 3BG, UK. 1 These authors contributed equally. 2 Correspondence may be addressed to: [email protected], [email protected] Istituto di Biofisica, Consiglio Nazionale delle Ricerche, via alla Ca...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.08.027